International Research Journal of Pharmacy (IRJP)

Phytochemical Screening of Withania Somnifera, Antioxidant, & Antimicrobial Activities in Various Regions of North Bihar with Respect to Soil and Climate

Nuzhat Parween, Dr Rima Kumari, Dr. Mustafa Kamal Ansari — Mon, 02 Sep 2024 00:00:00 +0000

Withania somnifera (Ashwagandha) is a prominent medicinal plant with a wide range of
therapeutic properties, attributed to its rich phytochemical profile. This study investigates the
influence of soil composition and climatic conditions on the phytochemical content,
antioxidant, and antimicrobial activities of Withania somnifera cultivated in different regions
of North Bihar. Samples were collected from five distinct regions, each with varying soil
types and microclimates. The phytochemical analysis revealed significant variations in the
concentration of bioactive compounds, such as withanolides and flavonoids. Antioxidant and
antimicrobial assays indicated that these variations are closely linked to the environmental
conditions of each region. The findings suggest that region-specific cultivation practices
could enhance the medicinal quality of Withania somnifera.

ASSOCIATION OF SERUM TOTAL PROTEIN AND SERUM ALBUMIN WITH OUTCOMES IN THE PATIENTS WITH SEVERE TRAUMATIC BRAIN INJURY

Shyam Sundar Yadav, Sushma BJ, Sanjeev Attry, Anil Kumar — Wed, 25 Sep 2024 00:00:00 +0000

Background: Traumatic brain injury is a derangement of natural anatomy and physiology of the brain or other
evidence due to external acceleration and deceleration motion that leads to temporary or permanent impairment of
brain function.
Aim: to investigate the role of total protein and albumin lead to resulting repairmen of brain function.
Methods: The study conducted after the approval of ethical board of hospital with traumatic brain injury patients who
passed the inclusion criteria of study.
Results: Total serum protein level (7.01 - 7.50) g/dl was found in maximum 21% of total TBI patients, whereas the
total serum albumin level (3.51 - 4.0) g/dl was found in maximum 29.9% of total TBI patients. The association
between severity of the patients with serum total protein (p=0.01340) was found highly significant where the
association between severity of the patients with total serum albumin (p=0.00375) in TBI patients were significantly
assessed. Similarly, on assessment of association with severe TBI patients with outcome were also reported significant
value with total serum protein (p=0.00177) & serum albumin (p=0.01130).
Conclusion: The estimated parameter were found highly significant levels of degree with the association based
outcomes revealed the result of Glasgow coma scale and Glasgow coma outcome scales in traumatic brain injury
patients.

STUDY TO ASSESS CLINICAL PROFILE AND LIPID PROFILE IN PATIENTS WITH XANTHELASMA PALPEBRARUM AT A TERTIARY CARE CENTRE

Dr Mahanthesh P, Dr. Vivek Khandekar — Mon, 30 Sep 2024 00:00:00 +0000

Background: A common sign of a lipid abnormality is xanthoma; the most common type is xanthelasma palpebrarum
(XP). On both the lower and upper eyelids, it appears as symmetrical, soft, velvety, yellowish papules and plaques. It
has been noted that Xanthelasma Palpebrarum is caused by acetylated low-density lipoprotein (LDL) and
macrophages
Materials and Methods: This comparative, cross-sectional study conducted in Dept. of Dermatology, in which 40
patients with XP as cases and 40 patients with non-inflammatory skin disorders as controls were selected as per the
inclusion and exclusion criteria matched as per the age and gender of our study.
Results: In our study, most of the patients with xanthelasma palpebrarum were females. Familial
hypercholesterolemia was more common in patients with XP as compared to controls group. Hypertriglyceridemia
and hypercholesterolemia was more common in cases group. The difference between mean values of triglycerides,
cholesterol, HDL, VLDL among the cases and control group was significant (p < 0.05).
Conclusion: We conclude that individuals with dyslipidemia are more likely to develop coronary artery disease, as
the majority of patients with Xanthelasma Palpebrarum have abnormal lipid levels. The mean serum values of several
lipid profile parameters (total cholesterol, HDL, TG, and VLDL) showed a significant difference in our investigation.